What are the two most common histopathological diagnoses for PLE?

What are the two most common histopathological diagnoses for PLE?

• A. CIE/IBD
• B. Intestinal lymphangiectasia
• C. CIE/IBD and Intestinal lymphangiectasia
• D. IBD and allergic enteritis

Answer: (C)

Protein-losing enteropathy arises when the gut loses proteins, and the tissue patterns you’re most likely to see reflect the two main mechanisms behind that loss. One pattern is inflammatory enteropathy (often labeled CIE/IBD), where the mucosa is inflamed and infiltrated by lymphocytes and plasma cells, sometimes with villous changes. This inflammation increases mucosal permeability and protein leakage into the gut lumen. The other pattern is intestinal lymphangiectasia, where the lymphatic vessels in the lamina propria are dilated or obstructed, causing protein-rich lymph to leak into the intestinal lumen. These two patterns together are by far the most common histopathologic diagnoses associated with PLE, so choosing the combo of inflammatory enteropathy and lymphangiectasia fits the typical histology you’d expect. Allergic enteritis can occur but is not one of the two most common histopathologic conclusions for PLE, and combining IBD with allergic enteritis doesn’t reflect the usual dominant patterns seen.

Protein-losing enteropathy arises when the gut loses proteins, and the tissue patterns you’re most likely to see reflect the two main mechanisms behind that loss. One pattern is inflammatory enteropathy (often labeled CIE/IBD), where the mucosa is inflamed and infiltrated by lymphocytes and plasma cells, sometimes with villous changes. This inflammation increases mucosal permeability and protein leakage into the gut lumen. The other pattern is intestinal lymphangiectasia, where the lymphatic vessels in the lamina propria are dilated or obstructed, causing protein-rich lymph to leak into the intestinal lumen.

These two patterns together are by far the most common histopathologic diagnoses associated with PLE, so choosing the combo of inflammatory enteropathy and lymphangiectasia fits the typical histology you’d expect. Allergic enteritis can occur but is not one of the two most common histopathologic conclusions for PLE, and combining IBD with allergic enteritis doesn’t reflect the usual dominant patterns seen.